Name | fusicoccin from fusicoccum amygdali |
Synonyms | Nsc113500 FUSICOCCIN Fucicoccin Fusicoccin a Fusicoccin-A(Fusicoccin fusicoccin from fusicoccum amygdali 3-[2-(Acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethylcyclopenta[a,d]-dicylo coten-4-yl-6 .alpha.-D-Glucopyranoside, 3-[2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6A,7,8,9,10A-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10A-dimethyldicyclopenta[A,D]cycloocten-4-yl 6-o-(1,1-dimethyl-2-propenyl)-, 3-acetate, [1S-[1.alpha.,3(R*),4.alpha.,5.beta.,6.beta.,6A.alpha.,9.beta.,10A.beta.]]- |
CAS | 20108-30-9 |
InChI | InChI=1/C36H56O12/c1-10-35(6,7)45-17-26-30(41)33(46-21(5)38)31(42)34(47-26)48-32-28-24(18(2)15-44-20(4)37)13-27(39)36(28,8)14-25-22(16-43-9)11-12-23(25)19(3)29(32)40/h10,14,18-19,22-23,26-27,29-34,39-42H,1,11-13,15-17H2,2-9H3/b25-14-/t18-,19-,22-,23+,26-,27+,29-,30-,31-,32-,33+,34-,36+/m1/s1 |
Molecular Formula | C36H56O12 |
Molar Mass | 680.82 |
Density | 1.24g/cm3 |
Boling Point | 760.2°C at 760 mmHg |
Flash Point | 227°C |
Vapor Presure | 1.12E-26mmHg at 25°C |
Appearance | White solid. |
Storage Condition | −20°C |
Refractive Index | 1.555 |
In vitro study | Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC 50 =29 mM). Fusicoccin A activates the plasma membrane H + -ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC 50 growth inhibitory concentration of fusicoccin A is 92 µM in the U373-MG cells and 83 µM in the Hs683 glioma cells. |
WGK Germany | 3 |
biological activity | Fusicoccin (Fusicoccin A), a fungal pyogenic toxin, stabilizer of 14-3-3 protein interaction. Fusicoccin stabilize the H -ATPase/14-3-3 complex in plants and maintain the activated state of the enzyme. Fusicoccin also stabilized the interaction of 14-3-3 proteins with binding partners containing C- terminal 14-3-3 recognition motifs, such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces the apoptosis of some cancer cells and has anti-cancer activity. |